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KMID : 1140120090140040329
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Cancer Prevention Research
2009 Volume.14 No. 4 p.329 ~ p.334
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19-nor-1α-25-Dihydroxyvitamin D2 (Paricalcitol) Induces Apoptosis in Gastric Cancer Cells
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Bae Woo-Kyun
Lee Ji-Hee
Park Myung-Suk
Ahn Jae-Sook
Hwang Jun-Eul
Shim Hyun-Jeong
Cho Sang-Hee
Chung Ik-Joo
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Abstract
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The active metabolite of vitamin D3 (1,25-dihydroxyvitamin D3, calcitriol) has shown potent antitumor activity for multiple cancers in vitro and in vivo models. Concerns about causing hypercalcemia by calcitriol and the desire for more potent agents have prompted the development of low-calcemic vitamin D analogs. The compound 19-nor-1?-25-dihydroxyvitamin D2 (paricalcitol) demonstrated anticancer effects on gastric cancer cell lines expressing vitamin D receptor (VDR). The expression of the VDR protein was increased by paricalcitol in a dose-dependent manner. Paricalcitol inhibited gastric cell growth and induced apoptosis in AGS, SNU719 and MKN45 cell lines. Paricalcitol increased the expression of the caspase-3 cleaved protein and decreased the expression of the anti-apoptotic Bcl-2 protein. Furthermore, paricalcitol promoted early and late apoptosis. This low-calcemic vitamin D analog was effective in vitro and is a promising agent for the prevention and treatment of gastric cancer.
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KEYWORD
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Paricalcitol (19-nor-1α-25-dihydroxyvitamin D2), Gastric cancer, 1, 25(OH)2D3, Apoptosis
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